(TMZ) - Oprah Winfrey just came out firing at Donald Sterling -- telling TMZ Sports, "We're off the plantation! The plantation days are over!"
The Big O just broke her silence on the Sterling situation while leaving CBS in NYC -- and told TMZ the ideal resolution would be for Magic Johnson to take over the Clippers ... "That would be really cool."
But despite the impact of the Sterling story -- and the fact President Obama even weighed in -- Oprah says it's not the biggest story of her lifetime ... that distinction goes to ANOTHER big case involving a huge sports star.
Check out the clip.